Influenza hemagglutinin-specific IgA Fc-effector functionality is restricted to stalk epitopes

In this study, we utilized a panel of human immunoglobulin (Ig) IgA monoclonal antibodies isolated from the plasmablasts of eight donors after 2014/2015 influenza virus vaccination (Fluarix) to study the binding and functional specificities of this isotype. In this cohort, isolated IgA monoclonal an...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Freyn, Alec W., Han, Julianna, Guthmiller, Jenna J., Bailey, Mark J., Neu, Karlynn, Turner, Hannah L., Rosado, Victoria C., Chromikova, Veronika, Huang, Min, Strohmeier, Shirin, Liu, Sean T. H., Simon, Viviana, Krammer, Florian, Ward, Andrew B., Palese, Peter, Wilson, Patrick C., Nachbagauer, Raffael
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2021
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7923359/
https://ncbi.nlm.nih.gov/pubmed/33593910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2018102118
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