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The glutamine antagonist prodrug JHU-083 slows malignant glioma growth and disrupts mTOR signaling
BACKGROUND: Metabolic reprogramming is a common feature in cancer, and it is critical to facilitate cancer cell growth. Isocitrate Dehydrogenase 1/2 (IDH1 and IDH2) mutations (IDHmut) are the most common genetic alteration in glioma grade II and III and secondary glioblastoma and these mutations inc...
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| Publicado no: | Neurooncol Adv |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7920530/ https://ncbi.nlm.nih.gov/pubmed/33681764 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdaa149 |
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