Glutamine Antagonist JHU083 Normalizes Aberrant Glutamate Production and Cognitive Deficits in the EcoHIV Murine Model of HIV-Associated Neurocognitive Disorders

HIV-associated neurocognitive disorders (HAND) have been linked to dysregulation of glutamate metabolism in the central nervous system (CNS) culminating in elevated extracellular glutamate and disrupted glutamatergic neurotransmission. Increased glutamate synthesis via upregulation of glutaminase (G...

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Publicado no:J Neuroimmune Pharmacol
Main Authors: Nedelcovych, Michael T., Kim, Boe-Hyun, Zhu, Xiaolei, Lovell, Lyndah E., Manning, Arena A., Kelschenbach, Jennifer, Hadas, Eran, Chao, Wei, Prchalová, Eva, Dash, Ranjeet P., Wu, Ying, Alt, Jesse, Thomas, Ajit G., Rais, Rana, Kamiya, Atsushi, Volsky, David J., Slusher, Barbara S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8207835/
https://ncbi.nlm.nih.gov/pubmed/31209775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11481-019-09859-w
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