N-(Pivaloyloxy)alkoxy-carbonyl Prodrugs of the Glutamine Antagonist 6-Diazo-5-oxo-L-norleucine (DON) as a Potential Treatment for HIV Associated Neurocognitive Disorders

Aberrant excitatory neurotransmission associated with overproduction of glutamate has been implicated in the development of HIV-associated neurocognitive disorders (HAND). The glutamine antagonist 6-diazo-5-oxo-L-norleucine (DON, 14) attenuates glutamate synthesis in HIV-infected microglia/macrophag...

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Vydáno v:J Med Chem
Hlavní autoři: Nedelcovych, Michael T., Tenora, Lukáš, Kim, Boe-Hyun, Kelschenbach, Jennifer, Chao, Wei, Hadas, Eran, Jančařík, Andrej, Prchalová, Eva, Zimmermann, Sarah C., Dash, Ranjeet P., Gadiano, Alexandra J., Garrett, Caroline, Furtmüller, Georg, Oh, Byoungchol, Brandacher, Gerald, Alt, Jesse, Majer, Pavel, Volsky, David J., Rais, Rana, Slusher, Barbara S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5795620/
https://ncbi.nlm.nih.gov/pubmed/28759224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b00966
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