Intranasal insulin therapy reverses hippocampal dendritic injury and cognitive impairment in a model of HIV-associated neurocognitive disorders in EcoHIV-infected mice

OBJECTIVE: Almost half of HIV-positive people on antiretroviral therapy have demonstrable mild neurocognitive impairment (HIV-NCI), even when virologically suppressed. Intranasal insulin therapy improves cognition in Alzheimer's disease and diabetes. Here we tested intranasal insulin therapy in...

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Vydáno v:AIDS
Hlavní autoři: Kim, Boe-Hyun, Kelschenbach, Jennifer, Borjabad, Alejandra, Hadas, Eran, He, Hongxia, Potash, Mary Jane, Nedelcovych, Michael T., Rais, Rana, Haughey, Norman J., McArthur, Justin C., Slusher, Barbara S., Volsky, David J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Lippincott Williams & Wilkins 2019
Témata:
Basic Science
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6457131/
https://ncbi.nlm.nih.gov/pubmed/30946151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0000000000002150
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