Glutamine Antagonist JHU-083 Normalizes Aberrant Hippocampal Glutaminase Activity and Improves Cognition in APOE4 Mice

BACKGROUND: Given the emergent aging population, the identification of effective treatments for Alzheimer’s disease (AD) is critical. OBJECTIVE: We investigated the therapeutic efficacy of JHU-083, a brain-penetrable glutamine antagonist, in treating AD using the humanized APOE4 knock-in mouse model...

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Bibliografiset tiedot
Julkaisussa:J Alzheimers Dis
Päätekijät: Hollinger, Kristen R., Zhu, Xiaolei, Khoury, Elizabeth S., Thomas, Ajit G., Liaw, Kevin, Tallon, Carolyn, Wu, Ying, Prchalova, Eva, Kamiya, Atsushi, Rojas, Camilo, Kannan, Sujatha, Slusher, Barbara S.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2020
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7678030/
https://ncbi.nlm.nih.gov/pubmed/32675407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-190588
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