Glutamine Antagonist JHU-083 Normalizes Aberrant Hippocampal Glutaminase Activity and Improves Cognition in APOE4 Mice

BACKGROUND: Given the emergent aging population, the identification of effective treatments for Alzheimer’s disease (AD) is critical. OBJECTIVE: We investigated the therapeutic efficacy of JHU-083, a brain-penetrable glutamine antagonist, in treating AD using the humanized APOE4 knock-in mouse model...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:J Alzheimers Dis
Autori principali: Hollinger, Kristen R., Zhu, Xiaolei, Khoury, Elizabeth S., Thomas, Ajit G., Liaw, Kevin, Tallon, Carolyn, Wu, Ying, Prchalova, Eva, Kamiya, Atsushi, Rojas, Camilo, Kannan, Sujatha, Slusher, Barbara S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7678030/
https://ncbi.nlm.nih.gov/pubmed/32675407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-190588
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi