The glutamine antagonist prodrug JHU-083 slows malignant glioma growth and disrupts mTOR signaling

BACKGROUND: Metabolic reprogramming is a common feature in cancer, and it is critical to facilitate cancer cell growth. Isocitrate Dehydrogenase 1/2 (IDH1 and IDH2) mutations (IDHmut) are the most common genetic alteration in glioma grade II and III and secondary glioblastoma and these mutations inc...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:Neurooncol Adv
Hoofdauteurs: Yamashita, Alex Shimura, da Costa Rosa, Marina, Stumpo, Vittorio, Rais, Rana, Slusher, Barbara S, Riggins, Gregory J
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2020
Onderwerpen:
Basic and Translational Investigations
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7920530/
https://ncbi.nlm.nih.gov/pubmed/33681764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdaa149
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items