Novel Glutamine Antagonist JHU395 Suppresses MYC-Driven Medulloblastoma Growth and Induces Apoptosis

Medulloblastoma is the most common malignant pediatric brain tumor. Amplification of c-MYC is a hallmark of a subset of poor-prognosis medulloblastoma. MYC upregulates glutamine metabolism across many types of cancer. We modified the naturally occurring glutamine antagonist 6-diazo-5-oxo-l-norleucin...

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Detalhes bibliográficos
Publicado no:J Neuropathol Exp Neurol
Main Authors: Pham, Khoa, Maxwell, Micah J, Sweeney, Heather, Alt, Jesse, Rais, Rana, Eberhart, Charles G, Slusher, Barbara S, Raabe, Eric H
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2021
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7985826/
https://ncbi.nlm.nih.gov/pubmed/33712838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnen/nlab018
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