MBRS-61. IN VIVO METABOLOMICS REVEALS A POTENT COMBINATION THERAPY FOR MYC-DRIVEN MEDULLOBLASTOMA

The MYC oncogene is associated with aggressive forms of medulloblastoma. MYC promotes oncogenesis partly by altering cellular metabolism. We hypothesized that MYC-driven medulloblastoma would be sensitive to the glutamine metabolic inhibitor 6-diazo-5-oxo-l-norleucine (DON). We found that 10uM DON t...

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Bibliografiset tiedot
Julkaisussa:Neuro Oncol
Päätekijät: Hanaford, Allison, Poore, Brad, Alt, Jesse, Slusher, Barbara, Eberhart, Charles, Raabe, Eric
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2018
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Abstracts
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012148/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.505
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