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TRTH-34. NOVEL ORAL PRODRUGS OF 6-DIAZO-5-OXO NORLEUCINE IMPROVE BRAIN PENETRATION AND DEMONSTRATE EFFICACY AGAINST MYC-DRIVEN ORTHOTOPIC MEDULLOBLASTOMA XENOGRAFTS
Increased MYC levels can alter cellular metabolism, creating a reliance on glutamine. Glutamine PET and MRI spectroscopy demonstrate that aggressive brain malignancies have increased uptake of glutamine and increased glutamate relative to normal brain, suggesting that agents targeting glutamine meta...
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| Publicado no: | Neuro Oncol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5475220/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.244 |
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