Unbiased metabolic profiling predicts sensitivity of high MYC-expressing atypical teratoid/rhabdoid tumors to glutamine inhibition with 6-diazo-5-oxo-L-norleucine

PURPOSE: Atypical teratoid/rhabdoid tumors are aggressive infantile brain tumors with poor survival. Recent advancements have highlighted significant molecular heterogeneity in AT/RT with an aggressive subgroup featuring over-expression of the MYC proto-oncogene. We perform the first comprehensive m...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Wang, Sabrina Z., Poore, Brad, Alt, Jesse, Price, Antoinette, Allen, Sariah J., Hanaford, Allison R., Kaur, Harpreet, Orr, Brent A., Slusher, Barbara S., Eberhart, Charles G., Raabe, Eric H., Rubens, Jeffrey A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6781869/
https://ncbi.nlm.nih.gov/pubmed/31300448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-0189
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