Unbiased metabolic profiling predicts sensitivity of high MYC-expressing atypical teratoid/rhabdoid tumors to glutamine inhibition with 6-diazo-5-oxo-L-norleucine

PURPOSE: Atypical teratoid/rhabdoid tumors are aggressive infantile brain tumors with poor survival. Recent advancements have highlighted significant molecular heterogeneity in AT/RT with an aggressive subgroup featuring over-expression of the MYC proto-oncogene. We perform the first comprehensive m...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Clin Cancer Res
Hlavní autoři: Wang, Sabrina Z., Poore, Brad, Alt, Jesse, Price, Antoinette, Allen, Sariah J., Hanaford, Allison R., Kaur, Harpreet, Orr, Brent A., Slusher, Barbara S., Eberhart, Charles G., Raabe, Eric H., Rubens, Jeffrey A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6781869/
https://ncbi.nlm.nih.gov/pubmed/31300448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-0189
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky