The novel glutamine antagonist prodrug JHU395 has antitumor activity in malignant peripheral nerve sheath tumor

The carbon and nitrogen components of glutamine are used for multiple biosynthetic processes by tumors. Glutamine metabolism and the therapeutic potential of glutamine antagonists (GA), however, are incompletely understood in malignant peripheral nerve sheath tumor (MPNST), an aggressive soft tissue...

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發表在:Mol Cancer Ther
Main Authors: Lemberg, Kathryn M., Zhao, Liang, Wu, Ying, Veeravalli, Vijayabhaskar, Alt, Jesse, Aguilar, Joanna Marie H., Dash, Ranjeet P., Lam, Jenny, Tenora, Lukáš, Rodriguez, Chabely, Nedelcovych, Michael T., Brayton, Cory, Majer, Pavel, Blakeley, Jaishri O., Rais, Rana, Slusher, Barbara S.
格式: Artigo
語言:Inglês
出版: 2019
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7007868/
https://ncbi.nlm.nih.gov/pubmed/31594823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-19-0319
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