The novel glutamine antagonist prodrug JHU395 has antitumor activity in malignant peripheral nerve sheath tumor

The carbon and nitrogen components of glutamine are used for multiple biosynthetic processes by tumors. Glutamine metabolism and the therapeutic potential of glutamine antagonists (GA), however, are incompletely understood in malignant peripheral nerve sheath tumor (MPNST), an aggressive soft tissue...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Lemberg, Kathryn M., Zhao, Liang, Wu, Ying, Veeravalli, Vijayabhaskar, Alt, Jesse, Aguilar, Joanna Marie H., Dash, Ranjeet P., Lam, Jenny, Tenora, Lukáš, Rodriguez, Chabely, Nedelcovych, Michael T., Brayton, Cory, Majer, Pavel, Blakeley, Jaishri O., Rais, Rana, Slusher, Barbara S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7007868/
https://ncbi.nlm.nih.gov/pubmed/31594823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-19-0319
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