Enhanced Oral Bioavailability of 2-(Phosphonomethyl)-pentanedioic Acid (2-PMPA) from its (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl (ODOL)-Based Prodrugs

2-(Phosphonomethyl)-pentanedioic acid (2-PMPA) is a potent (IC(50) = 300 pM) and selective inhibitor of glutamate carboxypeptidase II (GCPII) with efficacy in multiple neurological and psychiatric disease preclinical models and more recently in models of inflammatory bowel disease (IBD) and cancer....

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Vydáno v:Mol Pharm
Hlavní autoři: Dash, Ranjeet P., Tichý, Tomáš, Veeravalli, Vijayabhaskar, Lam, Jenny, Alt, Jesse, Wu, Ying, Tenora, Lukáš, Majer, Pavel, Slusher, Barbara S., Rais, Rana
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7978038/
https://ncbi.nlm.nih.gov/pubmed/31503493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.9b00637
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