Enhanced Oral Bioavailability of 2-(Phosphonomethyl)-pentanedioic Acid (2-PMPA) from its (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl (ODOL)-Based Prodrugs

2-(Phosphonomethyl)-pentanedioic acid (2-PMPA) is a potent (IC(50) = 300 pM) and selective inhibitor of glutamate carboxypeptidase II (GCPII) with efficacy in multiple neurological and psychiatric disease preclinical models and more recently in models of inflammatory bowel disease (IBD) and cancer....

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Detalhes bibliográficos
Publicado no:Mol Pharm
Main Authors: Dash, Ranjeet P., Tichý, Tomáš, Veeravalli, Vijayabhaskar, Lam, Jenny, Alt, Jesse, Wu, Ying, Tenora, Lukáš, Majer, Pavel, Slusher, Barbara S., Rais, Rana
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7978038/
https://ncbi.nlm.nih.gov/pubmed/31503493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.9b00637
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