Enhanced Oral Bioavailability of 2-(Phosphonomethyl)-pentanedioic Acid (2-PMPA) from its (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl (ODOL)-Based Prodrugs

2-(Phosphonomethyl)-pentanedioic acid (2-PMPA) is a potent (IC(50) = 300 pM) and selective inhibitor of glutamate carboxypeptidase II (GCPII) with efficacy in multiple neurological and psychiatric disease preclinical models and more recently in models of inflammatory bowel disease (IBD) and cancer....

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Pharm
Egile Nagusiak: Dash, Ranjeet P., Tichý, Tomáš, Veeravalli, Vijayabhaskar, Lam, Jenny, Alt, Jesse, Wu, Ying, Tenora, Lukáš, Majer, Pavel, Slusher, Barbara S., Rais, Rana
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7978038/
https://ncbi.nlm.nih.gov/pubmed/31503493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.9b00637
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