Enhanced Brain Delivery of 2-(Phosphonomethyl)pentanedioic Acid Following Intranasal Administration of Its γ-Substituted Ester Prodrugs

2-(Phosphonomethyl)pentanedioic acid (2-PMPA) is a potent and selective inhibitor of glutamate carboxypeptidase-II (GCPII) with efficacy in multiple neurological and psychiatric disease models, but its clinical utility is hampered by low brain penetration due to the inclusion of multiple acidic func...

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Detalhes bibliográficos
Publicado no:Mol Pharm
Main Authors: Nedelcovych, Michael, Dash, Ranjeet P., Tenora, Lukáś̌, Zimmermann, Sarah C., Gadiano, Alexandra J., Garrett, Caroline, Alt, Jesse, Hollinger, Kristen R., Pommier, Elie, Jančaří̌k, Andrej, Rojas, Camilo, Thomas, Ajit G., Wu, Ying, Wozniak, Krystyna, Majer, Pavel, Slusher, Barbara S., Rais, Rana
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5795618/
https://ncbi.nlm.nih.gov/pubmed/28763226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.7b00231
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