The novel glutamine antagonist prodrug JHU395 has antitumor activity in malignant peripheral nerve sheath tumor

The carbon and nitrogen components of glutamine are used for multiple biosynthetic processes by tumors. Glutamine metabolism and the therapeutic potential of glutamine antagonists (GA), however, are incompletely understood in malignant peripheral nerve sheath tumor (MPNST), an aggressive soft tissue...

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Gepubliceerd in:Mol Cancer Ther
Hoofdauteurs: Lemberg, Kathryn M., Zhao, Liang, Wu, Ying, Veeravalli, Vijayabhaskar, Alt, Jesse, Aguilar, Joanna Marie H., Dash, Ranjeet P., Lam, Jenny, Tenora, Lukáš, Rodriguez, Chabely, Nedelcovych, Michael T., Brayton, Cory, Majer, Pavel, Blakeley, Jaishri O., Rais, Rana, Slusher, Barbara S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7007868/
https://ncbi.nlm.nih.gov/pubmed/31594823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-19-0319
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