Targeting a Braf/Mapk pathway rescues podocyte lipid peroxidation in CoQ-deficiency kidney disease

Mutations affecting mitochondrial coenzyme Q (CoQ) biosynthesis lead to kidney failure due to selective loss of podocytes, essential cells of the kidney filter. Curiously, neighboring tubular epithelial cells are spared early in disease despite higher mitochondrial content. We sought to illuminate n...

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Publicat a:J Clin Invest
Autors principals: Sidhom, Eriene-Heidi, Kim, Choah, Kost-Alimova, Maria, Ting, May Theng, Keller, Keith, Avila-Pacheco, Julian, Watts, Andrew J.B., Vernon, Katherine A., Marshall, Jamie L., Reyes-Bricio, Estefanía, Racette, Matthew, Wieder, Nicolas, Kleiner, Giulio, Grinkevich, Elizabeth J., Chen, Fei, Weins, Astrid, Clish, Clary B., Shaw, Jillian L., Quinzii, Catarina M., Greka, Anna
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2021
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7919729/
https://ncbi.nlm.nih.gov/pubmed/33444290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI141380
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