Targeting a Braf/Mapk pathway rescues podocyte lipid peroxidation in CoQ-deficiency kidney disease

Mutations affecting mitochondrial coenzyme Q (CoQ) biosynthesis lead to kidney failure due to selective loss of podocytes, essential cells of the kidney filter. Curiously, neighboring tubular epithelial cells are spared early in disease despite higher mitochondrial content. We sought to illuminate n...

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Detalles Bibliográficos
Publicado en:J Clin Invest
Main Authors: Sidhom, Eriene-Heidi, Kim, Choah, Kost-Alimova, Maria, Ting, May Theng, Keller, Keith, Avila-Pacheco, Julian, Watts, Andrew J.B., Vernon, Katherine A., Marshall, Jamie L., Reyes-Bricio, Estefanía, Racette, Matthew, Wieder, Nicolas, Kleiner, Giulio, Grinkevich, Elizabeth J., Chen, Fei, Weins, Astrid, Clish, Clary B., Shaw, Jillian L., Quinzii, Catarina M., Greka, Anna
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7919729/
https://ncbi.nlm.nih.gov/pubmed/33444290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI141380
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