Single cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantation

Human iPSC-derived kidney organoids have the potential to revolutionize discovery, but assessing their consistency and reproducibility across iPSC lines, and reducing the generation of off-target cells remain an open challenge. Here, we profile four human iPSC lines for a total of 450,118 single cel...

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Udgivet i:Nat Commun
Main Authors: Subramanian, Ayshwarya, Sidhom, Eriene-Heidi, Emani, Maheswarareddy, Vernon, Katherine, Sahakian, Nareh, Zhou, Yiming, Kost-Alimova, Maria, Slyper, Michal, Waldman, Julia, Dionne, Danielle, Nguyen, Lan T., Weins, Astrid, Marshall, Jamie L., Rosenblatt-Rosen, Orit, Regev, Aviv, Greka, Anna
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6884507/
https://ncbi.nlm.nih.gov/pubmed/31784515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13382-0
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