A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment

Despite the development of effective therapies, a substantial proportion of asthmatics continue to have uncontrolled symptoms, airflow limitation, and exacerbations. Transient receptor potential cation channel member A1 (TRPA1) agonists are elevated in human asthmatic airways, and in rodents, TRPA1...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:J Exp Med
Hlavní autoři: Balestrini, Alessia, Joseph, Victory, Dourado, Michelle, Reese, Rebecca M., Shields, Shannon D., Rougé, Lionel, Bravo, Daniel D., Chernov-Rogan, Tania, Austin, Cary D., Chen, Huifen, Wang, Lan, Villemure, Elisia, Shore, Daniel G.M., Verma, Vishal A., Hu, Baihua, Chen, Yong, Leong, Laurie, Bjornson, Chris, Hötzel, Kathy, Gogineni, Alvin, Lee, Wyne P., Suto, Eric, Wu, Xiumin, Liu, John, Zhang, Juan, Gandham, Vineela, Wang, Jianyong, Payandeh, Jian, Ciferri, Claudio, Estevez, Alberto, Arthur, Christopher P., Kortmann, Jens, Wong, Ryan L., Heredia, Jose E., Doerr, Jonas, Jung, Min, Vander Heiden, Jason A., Roose-Girma, Merone, Tam, Lucinda, Barck, Kai H., Carano, Richard A.D., Ding, Han Ting, Brillantes, Bobby, Tam, Christine, Yang, Xiaoying, Gao, Simon S., Ly, Justin Q., Liu, Liling, Chen, Liuxi, Liederer, Bianca M., Lin, Joseph H., Magnuson, Steven, Chen, Jun, Hackos, David H., Elstrott, Justin, Rohou, Alexis, Safina, Brian S., Volgraf, Matthew, Bauer, Rebecca N., Riol-Blanco, Lorena
Médium: Artigo
Jazyk:Inglês
Vydáno: Rockefeller University Press 2021
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7918756/
https://ncbi.nlm.nih.gov/pubmed/33620419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20201637
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky