TRPA1 modulation by piperidine carboxamides suggests an evolutionarily conserved binding site and gating mechanism

The transient receptor potential ankyrin 1 (TRPA1) channel functions as an irritant sensor and is a therapeutic target for treating pain, itch, and respiratory diseases. As a ligand-gated channel, TRPA1 can be activated by electrophilic compounds such as allyl isothiocyanate (AITC) through covalent...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Chernov-Rogan, Tania, Gianti, Eleonora, Liu, Chang, Villemure, Elisia, Cridland, Andrew P., Hu, Xiaoyu, Ballini, Elisa, Lange, Wienke, Deisemann, Heike, Li, Tianbo, Ward, Stuart I., Hackos, David H., Magnuson, Steven, Safina, Brian, Klein, Michael L., Volgraf, Matthew, Carnevale, Vincenzo, Chen, Jun
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2019
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6926016/
https://ncbi.nlm.nih.gov/pubmed/31796582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1913929116
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