A non-covalent ligand reveals biased agonism of the TRPA1 ion channel

SUMMARY: The TRPA1 ion channel is activated by electrophilic compounds through covalent modification of intracellular cysteine residues. How non-covalent agonists activate the channel, and whether covalent and non-covalent agonists elicit the same physiological responses, are not understood. Here, w...

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Publicado no:Neuron
Main Authors: Liu, Chang, Reese, Rebecca, Vu, Simon, Rougé, Lionel, Shields, Shannon D, Kakiuchi-Kiyota, Satoko, Chen, Huifen, Johnson, Kevin, Shi, Yu Patrick, Chernov-Rogan, Tania, Greiner, Demi Maria Zabala, Kohli, Pawan Bir, Hackos, David, Brillantes, Bobby, Tam, Christine, Li, Tianbo, Wang, Jianyong, Safina, Brian, Magnuson, Steve, Volgraf, Matthew, Payandeh, Jian, Zheng, Jie, Rohou, Alexis, Chen, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8244166/
https://ncbi.nlm.nih.gov/pubmed/33152265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2020.10.014
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