A non-covalent ligand reveals biased agonism of the TRPA1 ion channel

SUMMARY: The TRPA1 ion channel is activated by electrophilic compounds through covalent modification of intracellular cysteine residues. How non-covalent agonists activate the channel, and whether covalent and non-covalent agonists elicit the same physiological responses, are not understood. Here, w...

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Pubblicato in:Neuron
Autori principali: Liu, Chang, Reese, Rebecca, Vu, Simon, Rougé, Lionel, Shields, Shannon D, Kakiuchi-Kiyota, Satoko, Chen, Huifen, Johnson, Kevin, Shi, Yu Patrick, Chernov-Rogan, Tania, Greiner, Demi Maria Zabala, Kohli, Pawan Bir, Hackos, David, Brillantes, Bobby, Tam, Christine, Li, Tianbo, Wang, Jianyong, Safina, Brian, Magnuson, Steve, Volgraf, Matthew, Payandeh, Jian, Zheng, Jie, Rohou, Alexis, Chen, Jun
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8244166/
https://ncbi.nlm.nih.gov/pubmed/33152265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2020.10.014
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