Modified Adenovirus Prime-Protein Boost Clade C HIV Vaccine Strategy Results in Reduced Viral DNA in Blood and Tissues Following Tier 2 SHIV Challenge

Designing immunogens and improving delivery methods eliciting protective immunity is a paramount goal of HIV vaccine development. A comparative vaccine challenge study was performed in rhesus macaques using clade C HIV Envelope (Env) and SIV Gag antigens. One group was vaccinated using co-immunizati...

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發表在:Front Immunol
Main Authors: Malherbe, Delphine C., Vang, Lo, Mendy, Jason, Barnette, Philip T., Spencer, David A., Reed, Jason, Kareko, Bettie W., Sather, D. Noah, Pandey, Shilpi, Wibmer, Constantinos K., Robins, Harlan, Fuller, Deborah H., Park, Byung, Lakhashe, Samir K., Wilson, James M., Axthelm, Michael K., Ruprecht, Ruth M., Moore, Penny L., Sacha, Jonah B., Hessell, Ann J., Alexander, Jeff, Haigwood, Nancy L.
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2021
主題:
Immunology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7917243/
https://ncbi.nlm.nih.gov/pubmed/33658998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.626464
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