Modified Adenovirus Prime-Protein Boost Clade C HIV Vaccine Strategy Results in Reduced Viral DNA in Blood and Tissues Following Tier 2 SHIV Challenge

Designing immunogens and improving delivery methods eliciting protective immunity is a paramount goal of HIV vaccine development. A comparative vaccine challenge study was performed in rhesus macaques using clade C HIV Envelope (Env) and SIV Gag antigens. One group was vaccinated using co-immunizati...

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Publicado en:Front Immunol
Autores principales: Malherbe, Delphine C., Vang, Lo, Mendy, Jason, Barnette, Philip T., Spencer, David A., Reed, Jason, Kareko, Bettie W., Sather, D. Noah, Pandey, Shilpi, Wibmer, Constantinos K., Robins, Harlan, Fuller, Deborah H., Park, Byung, Lakhashe, Samir K., Wilson, James M., Axthelm, Michael K., Ruprecht, Ruth M., Moore, Penny L., Sacha, Jonah B., Hessell, Ann J., Alexander, Jeff, Haigwood, Nancy L.
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7917243/
https://ncbi.nlm.nih.gov/pubmed/33658998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.626464
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