Rapid Induction of Multifunctional Antibodies in Rabbits and Macaques by Clade C HIV-1 CAP257 Envelopes Circulating During Epitope-Specific Neutralization Breadth Development

We report here on HIV-1 immunization results in rabbits and macaques co-immunized with clade C gp160 DNA and gp140 trimeric envelope vaccines, a strategy similar to a recent clinical trial that showed improved speed and magnitude of humoral responses. Clade C envelopes were isolated from CAP257, an...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Malherbe, Delphine C., Wibmer, Constantinos Kurt, Nonyane, Molati, Reed, Jason, Sather, D. Noah, Spencer, David A., Schuman, Jason T., Guo, Biwei, Pandey, Shilpi, Robins, Harlan, Park, Byung, Fuller, Deborah H., Sacha, Jonah B., Moore, Penny L., Hessell, Ann J., Haigwood, Nancy L.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7280454/
https://ncbi.nlm.nih.gov/pubmed/32582155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00984
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