Rapid Induction of Multifunctional Antibodies in Rabbits and Macaques by Clade C HIV-1 CAP257 Envelopes Circulating During Epitope-Specific Neutralization Breadth Development

We report here on HIV-1 immunization results in rabbits and macaques co-immunized with clade C gp160 DNA and gp140 trimeric envelope vaccines, a strategy similar to a recent clinical trial that showed improved speed and magnitude of humoral responses. Clade C envelopes were isolated from CAP257, an...

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Pubblicato in:Front Immunol
Autori principali: Malherbe, Delphine C., Wibmer, Constantinos Kurt, Nonyane, Molati, Reed, Jason, Sather, D. Noah, Spencer, David A., Schuman, Jason T., Guo, Biwei, Pandey, Shilpi, Robins, Harlan, Park, Byung, Fuller, Deborah H., Sacha, Jonah B., Moore, Penny L., Hessell, Ann J., Haigwood, Nancy L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7280454/
https://ncbi.nlm.nih.gov/pubmed/32582155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00984
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