Combination Adenovirus and Protein Vaccines Prevent Infection or Reduce Viral Burden after Heterologous Clade C Simian-Human Immunodeficiency Virus Mucosal Challenge

HIV vaccine development is focused on designing immunogens and delivery methods that elicit protective immunity. We evaluated a combination of adenovirus (Ad) vectors expressing HIV 1086.C (clade C) envelope glycoprotein (Env), SIV Gag p55, and human pegivirus GBV-C E2 glycoprotein. We compared repl...

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Bibliographic Details
Published in:J Virol
Main Authors: Malherbe, Delphine C., Mendy, Jason, Vang, Lo, Barnette, Philip T., Reed, Jason, Lakhashe, Samir K., Owuor, Joshua, Gach, Johannes S., Legasse, Alfred W., Axthelm, Michael K., LaBranche, Celia C., Montefiori, David, Forthal, Donald N., Park, Byung, Wilson, James M., McLinden, James H., Xiang, Jinhua, Stapleton, Jack T., Sacha, Jonah B., Haynes, Barton F., Liao, Hua-Xin, Ruprecht, Ruth M., Smith, Jonathan, Gurwith, Marc, Haigwood, Nancy L., Alexander, Jeff
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2018
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752948/
https://ncbi.nlm.nih.gov/pubmed/29093095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01092-17
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