Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators

The evolution of gamma-secretase modulators (GSMs) through the introduction of novel heterocycles with the goal of aligning activity for reducing the levels of Aβ42 and properties consistent with a drug-like molecule are described. The insertion of a methoxypyridine motif within the tetracyclic scaf...

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Detaylı Bibliyografya
Yayımlandı:Bioorg Med Chem
Asıl Yazarlar: Rynearson, Kevin D., Buckle, Ronald N., Herr, R. Jason, Mayhew, Nicholas J., Chen, Xinchao, Paquette, William D., Sakwa, Samuel A., Yang, Jinhai, Barnes, Keith D., Nguyen, Phuong, Mobley, William C., Johnson, Graham, Lin, Juinn H., Tanzi, Rudolph E., Wagner, Steven L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7917164/
https://ncbi.nlm.nih.gov/pubmed/33007551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2020.115734
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