Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators

The evolution of gamma-secretase modulators (GSMs) through the introduction of novel heterocycles with the goal of aligning activity for reducing the levels of Aβ42 and properties consistent with a drug-like molecule are described. The insertion of a methoxypyridine motif within the tetracyclic scaf...

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Veröffentlicht in:Bioorg Med Chem
Hauptverfasser: Rynearson, Kevin D., Buckle, Ronald N., Herr, R. Jason, Mayhew, Nicholas J., Chen, Xinchao, Paquette, William D., Sakwa, Samuel A., Yang, Jinhai, Barnes, Keith D., Nguyen, Phuong, Mobley, William C., Johnson, Graham, Lin, Juinn H., Tanzi, Rudolph E., Wagner, Steven L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7917164/
https://ncbi.nlm.nih.gov/pubmed/33007551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2020.115734
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