Soluble Gamma-secretase Modulators Attenuate Alzheimer's β-amyloid Pathology and Induce Conformational Changes in Presenilin 1

A central pathogenic event of Alzheimer's disease (AD) is the accumulation of the Aβ42 peptide, which is generated from amyloid-β precursor protein (APP) via cleavages by β- and γ-secretase. We have developed a class of soluble 2-aminothiazole γ-secretase modulators (SGSMs) that preferentially...

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發表在:EBioMedicine
Main Authors: Raven, Frank, Ward, Joseph F., Zoltowska, Katarzyna M., Wan, Yu, Bylykbashi, Enjana, Miller, Sean J., Shen, Xunuo, Choi, Se Hoon, Rynearson, Kevin D., Berezovska, Oksana, Wagner, Steven L., Tanzi, Rudolph E., Zhang, Can
格式: Artigo
語言:Inglês
出版: Elsevier 2017
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Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5652037/
https://ncbi.nlm.nih.gov/pubmed/28919280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2017.08.028
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