Soluble Gamma-secretase Modulators Attenuate Alzheimer's β-amyloid Pathology and Induce Conformational Changes in Presenilin 1

A central pathogenic event of Alzheimer's disease (AD) is the accumulation of the Aβ42 peptide, which is generated from amyloid-β precursor protein (APP) via cleavages by β- and γ-secretase. We have developed a class of soluble 2-aminothiazole γ-secretase modulators (SGSMs) that preferentially...

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Detaylı Bibliyografya
Yayımlandı:EBioMedicine
Asıl Yazarlar: Raven, Frank, Ward, Joseph F., Zoltowska, Katarzyna M., Wan, Yu, Bylykbashi, Enjana, Miller, Sean J., Shen, Xunuo, Choi, Se Hoon, Rynearson, Kevin D., Berezovska, Oksana, Wagner, Steven L., Tanzi, Rudolph E., Zhang, Can
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier 2017
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5652037/
https://ncbi.nlm.nih.gov/pubmed/28919280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2017.08.028
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