Wordt geladen...
Soluble Gamma-secretase Modulators Attenuate Alzheimer's β-amyloid Pathology and Induce Conformational Changes in Presenilin 1
A central pathogenic event of Alzheimer's disease (AD) is the accumulation of the Aβ42 peptide, which is generated from amyloid-β precursor protein (APP) via cleavages by β- and γ-secretase. We have developed a class of soluble 2-aminothiazole γ-secretase modulators (SGSMs) that preferentially...
Bewaard in:
| Gepubliceerd in: | EBioMedicine |
|---|---|
| Hoofdauteurs: | , , , , , , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Elsevier
2017
|
| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5652037/ https://ncbi.nlm.nih.gov/pubmed/28919280 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2017.08.028 |
| Tags: |
Voeg label toe
Geen labels, Wees de eerste die dit record labelt!
|