Molecular imaging of Alzheimer’s disease–related gamma-secretase in mice and nonhuman primates

The pathogenesis of Alzheimer’s disease (AD) is primarily driven by brain accumulation of the amyloid-β-42 (Aβ(42)) peptide generated from the amyloid-β precursor protein (APP) via cleavages by β- and γ-secretase. γ-Secretase is a prime drug target for AD; however, its brain regional expression and...

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Detalles Bibliográficos
Publicado en:J Exp Med
Main Authors: Xu, Yulong, Wang, Changning, Wey, Hsiao-Ying, Liang, Yingxia, Chen, Zude, Choi, Se Hoon, Ran, Chongzhao, Rynearson, Kevin D., Bernales, Daniela R., Koegel, Robert E., Fiedler, Stephanie A., Striar, Robin, Wagner, Steven L., Tanzi, Rudolph E., Zhang, Can
Formato: Artigo
Idioma:Inglês
Publicado: Rockefeller University Press 2020
Assuntos:
Brief Definitive Report
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7553790/
https://ncbi.nlm.nih.gov/pubmed/32936886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20182266
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