PPARγ-p53-Mediated Vasculoregenerative Program to Reverse Pulmonary Hypertension

RATIONALE: In pulmonary arterial hypertension (PAH), endothelial dysfunction and obliterative vascular disease are associated with DNA damage and impaired signaling of bone morphogenetic protein type 2 receptor (BMPR2) via two downstream transcription factors, PPARγ and p53. OBJECTIVE: We investigat...

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Publicado no:Circ Res
Main Authors: Hennigs, Jan K., Cao, Aiqin, Li, Caiyun G., Shi, Minyi, Mienert, Julia, Miyagawa, Kazuya, Körbelin, Jakob, Marciano, David P., Chen, Pin-I, Roughley, Matthew, Elliott, Matthew V., Harper, Rebecca L., Bill, Matthew, Chappell, James, Moonen, Jan-Renier, Diebold, Isabel, Wang, Lingli, Snyder, Michael P, Rabinovitch, Marlene
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7908816/
https://ncbi.nlm.nih.gov/pubmed/33322916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.119.316339
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