PRPS1-mediated purine biosynthesis is critical for pluripotent stem cell survival and stemness

Pluripotent stem cells (PSCs) have a unique energetic and biosynthetic metabolism compared with typically differentiated cells. However, the metabolism profiling of PSCs and its underlying mechanism are still unclear. Here, we report PSCs metabolism profiling and identify the purine synthesis enzyme...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Aging (Albany NY)
Prif Awduron: Yang, Yi, Song, Lili, Huang, Xia, Feng, Yanan, Zhang, Yingwen, Liu, Yanfeng, Li, Shanshan, Zhan, Zhiyan, Zheng, Liang, Feng, Haizhong, Li, Yanxin
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Impact Journals 2021
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7906169/
https://ncbi.nlm.nih.gov/pubmed/33493137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.202372
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