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PUMA facilitates EMI1-promoted cytoplasmic Rad51 ubiquitination and inhibits DNA repair in stem and progenitor cells

Maintenance of genetic stability via proper DNA repair in stem and progenitor cells is essential for the tissue repair and regeneration, while preventing cell transformation after damage. Loss of PUMA dramatically increases the survival of mice after exposure to a lethal dose of ionizing radiation (...

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Detalhes bibliográficos
Publicado no:Signal Transduct Target Ther
Main Authors: Kang, Jin Wook, Zhan, Zhiyan, Ji, Guangzhen, Sang, Youzhou, Zhou, Daohong, Li, Yanxin, Feng, Haizhong, Cheng, Tao
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8009889/
https://ncbi.nlm.nih.gov/pubmed/33785736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41392-021-00510-w
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