PUMA facilitates EMI1-promoted cytoplasmic Rad51 ubiquitination and inhibits DNA repair in stem and progenitor cells

Maintenance of genetic stability via proper DNA repair in stem and progenitor cells is essential for the tissue repair and regeneration, while preventing cell transformation after damage. Loss of PUMA dramatically increases the survival of mice after exposure to a lethal dose of ionizing radiation (...

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Vydáno v:Signal Transduct Target Ther
Hlavní autoři: Kang, Jin Wook, Zhan, Zhiyan, Ji, Guangzhen, Sang, Youzhou, Zhou, Daohong, Li, Yanxin, Feng, Haizhong, Cheng, Tao
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8009889/
https://ncbi.nlm.nih.gov/pubmed/33785736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41392-021-00510-w
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