PUMA facilitates EMI1-promoted cytoplasmic Rad51 ubiquitination and inhibits DNA repair in stem and progenitor cells

Maintenance of genetic stability via proper DNA repair in stem and progenitor cells is essential for the tissue repair and regeneration, while preventing cell transformation after damage. Loss of PUMA dramatically increases the survival of mice after exposure to a lethal dose of ionizing radiation (...

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Pubblicato in:Signal Transduct Target Ther
Autori principali: Kang, Jin Wook, Zhan, Zhiyan, Ji, Guangzhen, Sang, Youzhou, Zhou, Daohong, Li, Yanxin, Feng, Haizhong, Cheng, Tao
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8009889/
https://ncbi.nlm.nih.gov/pubmed/33785736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41392-021-00510-w
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