Human Rad51 mediated DNA unwinding is facilitated by conditions that favour Rad51-dsDNA aggregation

BACKGROUND: Human Rad51 (RAD51), analogous to its bacterial homolog, RecA, binds and unwinds double stranded DNA (dsDNA) in the presence of certain nucleotide cofactors. ATP hydrolysis is not required for this process, because even ATP non hydrolysable analogs like AMP-PNP and ATPγS, support DNA unw...

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Main Authors: Balakrishnan, Kamakshi, Krishnan, Neeraja M, Kulkarni, Anagha, Rao, Basuthkar J
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2009
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630921/
https://ncbi.nlm.nih.gov/pubmed/19133161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2091-10-2
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