Absence of cyclin-dependent kinase inhibitor p27 or p18 increases efficiency of iPSC generation without induction of iPSC genomic instability

Mechanisms underlying the generation of induced pluripotent stem cells (iPSC) and keeping iPSC stability remain to be further defined. Accumulated evidences showed that iPSC reprogramming may be controlled by the cell-division-rate-dependent model. Here we reported effects of absence of mouse p27 or...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Cell Death Dis
Main Authors: Zhan, Zhiyan, Song, Lili, Zhang, Weiwei, Gu, Haihui, Cheng, Haizi, Zhang, Yingwen, Yang, Yi, Ji, Guangzhen, Feng, Haizhong, Cheng, Tao, Li, Yanxin
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6426969/
https://ncbi.nlm.nih.gov/pubmed/30894510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1502-8
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