Inhibition of the Otub1/c-Maf axis by the herbal acevaltrate induces myeloma cell apoptosis

BACKGROUND: The oncogenic transcript factor c-Maf is stabilized by the deubiquitinase Otub1 and promotes myeloma cell proliferation and confers to chemoresistance. Inhibition of the Otub1/c-Maf axis is a promising therapeutic target, but there are no inhibitors reported on this specific axis. METHOD...

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Bibliographic Details
Published in:Cell Commun Signal
Main Authors: Sun, Tong, Xu, Yujia, Xu, Zhuan, Cao, Biyin, Zhang, Zubin, Wang, Qi, Kong, Yan, Mao, Xinliang
Format: Artigo
Language:Inglês
Published: BioMed Central 2021
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7905600/
https://ncbi.nlm.nih.gov/pubmed/33627137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-020-00676-w
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