The ubiquitin-conjugating enzyme UBE2O modulates c-Maf stability and induces myeloma cell apoptosis

BACKGROUND: UBE2O is proposed as a ubiquitin-conjugating enzyme, but its function was largely unknown. METHODS: Mass spectrometry was applied to identify c-Maf ubiquitination-associated proteins. Immunoprecipitation was applied for c-Maf and UBE2O interaction. Immunoblotting was used for Maf protein...

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Detalhes bibliográficos
Publicado no:J Hematol Oncol
Main Authors: Xu, Yujia, Zhang, Zubin, Li, Jie, Tong, Jiefei, Cao, Biyin, Taylor, Paul, Tang, Xiaowen, Wu, Depei, Moran, Michael F., Zeng, Yuanying, Mao, Xinliang
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5496436/
https://ncbi.nlm.nih.gov/pubmed/28673317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-017-0499-7
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