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Inhibition of the Otub1/c-Maf axis by the herbal acevaltrate induces myeloma cell apoptosis
BACKGROUND: The oncogenic transcript factor c-Maf is stabilized by the deubiquitinase Otub1 and promotes myeloma cell proliferation and confers to chemoresistance. Inhibition of the Otub1/c-Maf axis is a promising therapeutic target, but there are no inhibitors reported on this specific axis. METHOD...
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| Publicado no: | Cell Commun Signal |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7905600/ https://ncbi.nlm.nih.gov/pubmed/33627137 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-020-00676-w |
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