Inhibition of the deubiquitinase USP5 leads to c-Maf protein degradation and myeloma cell apoptosis

The deubiquitinase USP5 stabilizes c-Maf, a key transcription factor in multiple myeloma (MM), but the mechanisms and significance are unclear. In the present study, USP5 was found to interact with c-Maf and prevented it from degradation by decreasing its polyubiquitination level. Specifically, the...

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Publicado en:Cell Death Dis
Autores principales: Wang, Siyu, Juan, Jiaxiang, Zhang, Zubin, Du, Yanyun, Xu, Yujia, Tong, Jiefei, Cao, Biyin, Moran, Michael F, Zeng, Yuanying, Mao, Xinliang
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2017
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5636991/
https://ncbi.nlm.nih.gov/pubmed/28933784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.450
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