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Targeting a Helix-in-Groove Interaction Between E1 and E2 Blocks Ubiquitin Transfer
The ubiquitin-proteasome system (UPS) is a highly-regulated protein disposal process critical to cell survival. Inhibiting the pathway induces proteotoxic stress and can be effective cancer treatment. The therapeutic window observed upon proteosomal blockade has motivated multiple UPS-targeting stra...
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| Publicat a: | Nat Chem Biol |
|---|---|
| Autors principals: | , , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7904387/ https://ncbi.nlm.nih.gov/pubmed/32807965 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-0625-7 |
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