Targeting a Helix-in-Groove Interaction Between E1 and E2 Blocks Ubiquitin Transfer

The ubiquitin-proteasome system (UPS) is a highly-regulated protein disposal process critical to cell survival. Inhibiting the pathway induces proteotoxic stress and can be effective cancer treatment. The therapeutic window observed upon proteosomal blockade has motivated multiple UPS-targeting stra...

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Vydáno v:Nat Chem Biol
Hlavní autoři: Cathcart, Ann M., Bird, Gregory H., Wales, Thomas E., Herce, Henry D., Harvey, Edward P., Hauseman, Zachary J., Newman, Catherine E., Adhikary, Utsarga, Prew, Michelle S., Oo, Tun, Lee, Susan, Engen, John R., Walensky, Loren D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7904387/
https://ncbi.nlm.nih.gov/pubmed/32807965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-0625-7
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