Identification of a Structural Determinant for Selective Targeting of HDMX

p53 is a critical tumor suppressor protein that guards the human genome against mutations by inducing cell cycle arrest or apoptosis. Cancer cells subvert p53 by deletion, mutation, or overexpression of the negative regulators HDM2 and HDMX. For tumors that retain wild-type p53, its reactivation by...

Full description

Saved in:
Bibliographic Details
Published in:Structure
Main Authors: Ben-Nun, Yael, Seo, Hyuk-Soo, Harvey, Edward P., Hauseman, Zachary J., Wales, Thomas E., Newman, Catherine E., Cathcart, Ann M., Engen, John R., Dhe-Paganon, Sirano, Walensky, Loren D.
Format: Artigo
Language:Inglês
Published: 2020
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7427690/
https://ncbi.nlm.nih.gov/pubmed/32359398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2020.04.011
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items