Identification of a Structural Determinant for Selective Targeting of HDMX

p53 is a critical tumor suppressor protein that guards the human genome against mutations by inducing cell cycle arrest or apoptosis. Cancer cells subvert p53 by deletion, mutation, or overexpression of the negative regulators HDM2 and HDMX. For tumors that retain wild-type p53, its reactivation by...

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Publicado en:Structure
Autores principales: Ben-Nun, Yael, Seo, Hyuk-Soo, Harvey, Edward P., Hauseman, Zachary J., Wales, Thomas E., Newman, Catherine E., Cathcart, Ann M., Engen, John R., Dhe-Paganon, Sirano, Walensky, Loren D.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7427690/
https://ncbi.nlm.nih.gov/pubmed/32359398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2020.04.011
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