Targeting a Helix-in-Groove Interaction Between E1 and E2 Blocks Ubiquitin Transfer

The ubiquitin-proteasome system (UPS) is a highly-regulated protein disposal process critical to cell survival. Inhibiting the pathway induces proteotoxic stress and can be effective cancer treatment. The therapeutic window observed upon proteosomal blockade has motivated multiple UPS-targeting stra...

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Xehetasun bibliografikoak
Argitaratua izan da:Nat Chem Biol
Egile Nagusiak: Cathcart, Ann M., Bird, Gregory H., Wales, Thomas E., Herce, Henry D., Harvey, Edward P., Hauseman, Zachary J., Newman, Catherine E., Adhikary, Utsarga, Prew, Michelle S., Oo, Tun, Lee, Susan, Engen, John R., Walensky, Loren D.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7904387/
https://ncbi.nlm.nih.gov/pubmed/32807965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-0625-7
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