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A redox switch regulates the structure and function of anti-apoptotic BFL-1
Apoptosis is regulated by BCL-2 family proteins. Anti-apoptotic members suppress cell death by deploying a surface groove to capture the critical BH3 α-helix of pro-apoptotic members. Cancer cells hijack this mechanism by overexpressing anti-apoptotic BCL-2 family proteins to enforce cellular immort...
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| Publicado no: | Nat Struct Mol Biol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7544158/ https://ncbi.nlm.nih.gov/pubmed/32661419 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-0458-9 |
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