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Precision Targeting of BFL-1/A1 and an ATM Co-dependency in Human Cancer
Cancer cells overexpress a diversity of anti-apoptotic BCL-2 family proteins, such as BCL-2, MCL-1, and BFL-1/A1, to enforce cellular immortality. Thus, intensive drug development efforts have focused on targeting this class of oncogenic proteins to overcome treatment resistance. Whereas a selective...
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| Опубликовано в: : | Cell Rep |
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| Главные авторы: | , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6365304/ https://ncbi.nlm.nih.gov/pubmed/30257201 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.08.089 |
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