Precision Targeting of BFL-1/A1 and an ATM Co-dependency in Human Cancer

Cancer cells overexpress a diversity of anti-apoptotic BCL-2 family proteins, such as BCL-2, MCL-1, and BFL-1/A1, to enforce cellular immortality. Thus, intensive drug development efforts have focused on targeting this class of oncogenic proteins to overcome treatment resistance. Whereas a selective...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cell Rep
Auteurs principaux: Guerra, Rachel M., Bird, Gregory H., Harvey, Edward P., Dharia, Neekesh V., Korshavn, Kyle J., Prew, Michelle S., Stegmaier, Kimberly, Walensky, Loren D.
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6365304/
https://ncbi.nlm.nih.gov/pubmed/30257201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.08.089
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